The increasing growth of web usage has made the importance of search engines and their quality assessment more responsive to users’ needs. One of the approaches to quality assessment is user satisfaction. The use of a search engine depends on user satisfaction, which is a measure of the quality of the search engine. Many search engines have been built in Iran. Some of these engines are widely used in searching information on the web, and some are found in a database. Iran scientific information database (Ganj) is one of the databases that has its own search engine. It contains nearly 530,000 dissertations and thesis and is one of the key scientific databases in the country with many users. Assessing the satisfaction of users of this system with its broad audience is crucial. In this research, indicators based on E-Qual model were developed to evaluate users’ satisfaction with Ganj System. Indices developed based on the Delphi method were screened and localized to assess users’ satisfaction with Ganj System. User satisfaction was also assessed using an E-Qual questionnaire. The results of the data analysis of the 156 questionnaires collected show that usability, information, and service interaction are the significant determinants of users’ satisfaction with Ganj system, respectively. In terms of usability, the ease of working with Ganj is a top priority. Likewise, the ease of interaction with the system and the apparent attractiveness of the system were introduced as the main factors.