Cloud computing introduces new capabilities to organizations such as: cost efficiency, scalability, access to global markets, and ease of use, flexibility and rapid adaptability against environmental changes. Cloud computing provides an important role in organizational innovation and agility. In spite of great opportunities that this technology brings to organization, in many of organization, especially in developing countries, adoption and migration rate is low. Major problem is that in previous studies of cloud computing adoption, limited aspects have been taken into Consideration. In fact, a comprehensive framework that includes all affecting factors didn’t develop. In order to address this issue, this research by systematic literature review of previous selected research, using the Meta-synthesis approach to qualitative analyze and synthesize different factors affecting the adoption of cloud computing. Finally we propose the comprehensive framework. In this research after systematic search, 57 papers are selected for full content review. Based on Meta-synthesis approach, 94 Concepts, 20 sub-categories and 9 categories of adoption factors recognized and, a cloud computing adoption framework developed. Proposed framework is composed of nine categories such as the economical, technological, organizational, cultural, innovational, regulatory environment, business environment, infrastructure, knowledge based and individual. This framework validated by experts’ judgments. For Expert selecting, the snowball sampling method is applied and in a focus group meeting the adoption framework reviewed and finalized. Proposed adoption framework conducts manager to gain effective and efficient view of adoption factors before cloud computing migration and design strategic planning.