This research is an applied research in which the thematic and methodological trends of Iran library and information science research have been studied through a scientometric approach. The research community is comprised of all research papers and proceedings that have been published by Iranian researchers in the period from 1970 to 2016 in LIS journals indexed in The WOS. Citespace is used to analyze and visualize the Iranian Co-citation network. The cluster analysis of LIS Co-citation network of Iran in the period from 1970 to 2016 led to the identification of five clusters or specialties. The title of the largest and smallest specialties in terms of the entity frequency of each cluster was awarded with 17 and 7 abundances, respectively, to two “Web Impact Factor” and “Information Literacy” specialties. According to the results, metric studies have played a significant role in shaping the intellectual structure of library and information science of Iran in the period studied. The results of the analysis of landmark and pivot documents in the co-citation network of Iranian studies indicated that the “Web Impact Factor” and “Information Behavior” were the most significant and most Pivotal specialties among other recognized specialties. The results of the content analysis of the five detected clusters in terms of their methodological structure during the period from 1970 to 2016 showed that Iranian library and information science have been influenced a great deal by the methods of metric studies.