This study is to explore the cognitive components of therapists’ information seeking behavior in the diagnosis and treatment of mental disorders. According to the high power of neuroscience tools in the analysis of immediate cognitive components, Quantitative Electroencephalography (QEEG) was used. Following, five of the therapists were selected by random sampling from a variety of researchers and entered in the research process. To gather data, some tools such as QEEG and Morae software were used. The findings showed that the brain waves of the therapists in the early stages of Kuhlthau’s ISP revealed extensive cognitive activities. As the therapists moved on to the final stages of Kuhlthau’s ISP, these cognitive activities diminished and the brain emotions overcame. Based on the findings, the best step for librarian intervention to guide and assist clinicians was stage 3 of Kuhlthau’s ISP. Also, findings indicated that the therapists’ information seeking behavior in the cognitive actions section was similar to the Kuhlthau’s ISP Model. Finally, it can be concluded that based on modern neuroscience and information technology tools, one can provide a better understanding of the up-to-the-minute process of therapists’ information seeking behavior, and due to smart and personalized systems , provide at the right moment, the appropriate information to the users. This evolution can be a major step in promoting information seeking behavior and advancing in the user information needs momently.